Unlike most of the solid tumors, retinoblastoma tumors can be directly visualized. In-depth understanding of the clinical features, indications for appropriate imaging and protocol-based treatment for retinoblastoma have proven to be valuable in managing this intraocular malignancy. The treatment options for retinoblastoma have evolved significantly and now strive for better visual function salvage. There is, however, an undeniable disparity in presentation, accessibility of care, patient compliance and outcomes seen between the developed world and under-developed parts of the world. Experienced contributors from different parts of the world address the important aspects of retinoblastoma, namely epidemiology, tumor biology and genetics, clinical diagnosis, treatment options and recent advances in research.