The 2nd edition of Handbook of Retinal Disease: A Case-Based Approach offers a high-yield case-based model of a wide range of retinal presentations, from patients’ signs and symptoms to analyses of diagnostic results and comprehensive outlines of treatment plans. This updated version includes additional chapters, photos, and new imaging modalities that reflect the ever-changing and evolving way in which we diagnose and treat retinal pathology today. This book includes over 85 cases, each presented with a table that summarizes the clinical findings, differential diagnosis, questions to ask the patient, and recommended imaging. After a discussion of the diagnostic imaging results, a final diagnosis is put forward with a summary of recommended treatment, prognosis, and follow-up.